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  • Title: Amniotic fluid acetylcholinesterase isoenzyme patterns in the diagnosis of neural tube defects.
    Author: Buamah PK, Evans L, Ward AM.
    Journal: Clin Chim Acta; 1980 Mar 28; 102(2-3):147-51. PubMed ID: 6154546.
    Abstract:
    Acetylcholinesterase isoenzyme patterns were determined in amniotic fluid from 140 normal pregnancies and from 68 pregnancies with various fetal abnormalities. A fast acetylcholinesterase isoenzyme was detected in all cases of neural tube defect, exomphalos and intrauterine death. The fast isoenzyme was not seen in any of the normal pregnancies. Blood-contaminated amniotic fluids with false positive elevation of alphafetoprotein gave a single isoenzyme band. The qualitative demonstration of a fast acetylcholinesterase isoenzyme in amniotic fluid provides a useful adjunct to the alphafetoprotein assay in the prenatal diagnosis of neural tube defects.
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