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  • Title: Histamine release induced from rat mast cells by the ionophore A23187 in the absence of extracellular calcium.
    Author: Johansen T.
    Journal: Eur J Pharmacol; 1980 Apr 04; 62(4):329-34. PubMed ID: 6154590.
    Abstract:
    Isolated rat mast cells were used to study whether ionophore A23187 could induce histamine release by mobilizing cellular calcium. The histamine release was a slow process which was completed after about 20 min incubation with A23187. The A23187-induced histamine release was inhibited after incubation of the cells with EDTA for 1 h in a 37 degrees C water bath in calcium-free medium. Reintroduction of calcium in excess of EDTA induced the release of histamine. The observations suggest that A23187 can induce histamine release by mobilizing a cellular pool of calcium.
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