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  • Title: Efficient removal of abnormal immunoglobulin G from plasma of a multiple myeloma patient. Description of a new method for treatment of the hyperviscosity syndrome.
    Author: Ray PK, Besa E, Idiculla A, Rhoads JE, Bassett JG, Cooper DR.
    Journal: Cancer; 1980 May 15; 45(10):2633-8. PubMed ID: 6155195.
    Abstract:
    Patients with multiple myeloma who have complications secondary to hyperviscosity are treated by chemotherapy and/or plasmapheresis. Because the response to chemotherapy is usually delayed, plasmapheresis is required for the removal of larger concentrations of plasma proteins to avoid life-threatening complications. Until now there has been no available means to decrease the abnormal plasma proteins in a selective manner. This report describes a new method for the selective removal of immunoglobulin G from the plasma of a patient suffering from IgG-type multiple myeloma. Results obtained from plasmapheresis and selective immunoadsorption of IgG are compared. It appears that the technique described herein may offer a new, more efficient method for the palliative treatment of diseases associated with elevated concentrations of plasma immunoglobulin G.
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