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Pubmed for Handhelds

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  • Title: Pilot study of vinblastine and bleomycin combinations in the treatment of metastatic melanoma.
    Author: Nathanson L, Wittenberg BK.
    Journal: Cancer Treat Rep; 1980 Jan; 64(1):133-7. PubMed ID: 6155208.
    Abstract:
    Fourteen patients with advanced metastatic malignant melanoma were entered in a study with a combination of vinblastine and bleomycin (11 patients) or with this combination plus cis-dichlorodiammineplatinum(II) (three patients). Objective partial responses were seen in four of nine evaluable patients receiving vinblastine and bleomycin and in all three evaluable patients receiving vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II). Although there was significant toxicity, it appeared tolerable, and no drug deaths were reported. The three drug-combination may produce less severe toxicity while maintaining a high response rate.
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