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  • Title: Comparative studies of a monoclonal IgG lambda and two IgE kappa components from an individual patient: evidence for shared idiotypic determinants between the two IgE proteins but not with the IgG lambda protein.
    Author: Cornwell GG, Michaelsen TE, Sanders WH.
    Journal: Immunology; 1980 Apr; 39(4):511-7. PubMed ID: 6155327.
    Abstract:
    An IgG lambda and two IgE kappa proteins were isolated from the serum of a patient (DB) with anaemia associated with myelofibrosis. Idiotype-specific antisera produced against the three proteins were studied by precipitation in double immunodiffusion and by enzyme-linked immunosorbent assay (ELISA) and indicated that the two IgE kappa components shared idiotypic determinants while the IgG lambda protein did not show any cross-idiotypic reaction. The idiotypic determinants of the three proteins were not present in pooled normal serum, normal IgG, normal IgE or IgE from a patient with multiple myeloma.
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