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  • Title: The influence of ectopic heart beats in gated ventricular blood-pool studies.
    Author: Brash HM, Wraith PK, Hannan WJ, Dewhurst NG, Muir AL.
    Journal: J Nucl Med; 1980 Apr; 21(4):391-3. PubMed ID: 6155457.
    Abstract:
    Direct data collection from ventricular blood-pool studies were stored in frame mode in a computer and by means of a modified tape recorder, the blood-pool image and ECG were recorded on tape. At the end of the study the tape data were replayed into the computer. The ECG signal was passed through a trigger circuit that detected the R wave which was sampled by the computer once every msec. Contractions outside of the desired range could be rejected along with the subsequent contraction. Of seven patients whose calculated ejection fractions were changed by more than 0.03, all had frequent (one in 20) ectopic contractions. The distorted ventricular volume curves were effectively restructured by the constraining procedure, changing the end-systolic volume and EF. Computer modeling showed a linear relationship between the percent of ectopic contractions and the underestimate of ejection fraction. One ectopic beat in ten led to a 5% underestimate of EF.
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