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  • Title: [Effect of prednisolone on the intensity of nucleic acid synthesis by granulation tissue fibroblasts].
    Author: Dudnikova GN.
    Journal: Biull Eksp Biol Med; 1980 Apr; 89(4):470-2. PubMed ID: 6155956.
    Abstract:
    An experimental study was made of the effect exerted by prednisolone in a dose of 4 mg/kg body weight on wound healing. It was shown that prednisolone reduces the period of inflammation, accelerates the formation of granulation tissue and epidermis. All these effects are accompanied by diminution of the mitotic activity of fibroblasts and dramatic increase in the intensity of RNA synthesis in them. Dislocation of newly synthetized RNA from the nucleus to the cytoplasm proceeds at a greater rate as compared to control. The differentiation of fibroblasts is accelerated.
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