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  • Title: Cellular regulation of fetal hemoglobin production.
    Author: Papayannopoulou T, Stamatoyannopoulos G.
    Journal: Ann N Y Acad Sci; 1980; 344():206-18. PubMed ID: 6156624.
    Abstract:
    In this paper, we put together several observations from studies in erythroid cultures that suggest that the major regulatory events determining Hb F and Hb A formation in the red cells are taken at the level of erythroid stem cells. We outlined the evidence that suggests that the program of Hb F expression changes during the differentiation of the primitive progenitors, known as burst-forming units, and we raised several possibilities on how this differentiation-dependent change in developmental programs could be accomplished. Although many questions remain still unanswered, the work done so far suggests that the mechanisms of regulation of Hb F at the cellular level can be successfully probed with existing methodologies. Delineation of the cellular mechanism of Hb F regulation is required in order to find out whether the therapeutic manipulation of Hb F in the patient with Cooley's anemia is possible or not.
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