These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Tryptophol-induced change in Brain 5-hydroxytryptamine Metabolism.
    Author: Fukumori R, Minegishi A, Satoh T, Kitagawa H, Yanaura S.
    Journal: Psychopharmacology (Berl); 1980; 69(3):243-6. PubMed ID: 6158066.
    Abstract:
    The effects of tryptoiphol (TOL) on brain 5-hydroxytryptamine (5-HT) metabolism were studied. After TOL injection (200 mg/kg IP), brain 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels were increased, 5-HT synthesis rate was decreased, and monoamine oxidase (MAO) activity remained unchanged. Pretreatment of mice with p-chlorophenylalanine (PCPA), a potent inhibitor of 5-HT synthesis, did not affect the anticonvulsant action of TOL.. These results suggest that alteration of 5-HT metabolism after TOL injection is not directly related to the anticonvulsant action of TOL
    [Abstract] [Full Text] [Related] [New Search]