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  • Title: [Antiviral activity of murine interferons produced by bacterial and animal cell translation of messenger RNA].
    Author: Mamontova TV, Mentkevich LM, Orlova TG.
    Journal: Vopr Virusol; 1980; (1):63-7. PubMed ID: 6158177.
    Abstract:
    Interferon was produced by E. Coli bacteria and animal cell messenger-RNA--interferon translation (mRNA--IF). The activity of the interferon produced by simultaneous mRNA--IF translation in these two cellular systems was, approximately, similar. The interferons translated by bacteria and animal cells inhibited the cytopathic effect, reproduction and plaque-formation of vesicular stomatitis virus, and, to a greater extent, of mouse encephalomyocarditis virus. The virus titration was carried out by the dye-uptake method. The bacteria-translated interferon (BTIF) was more susceptible to the indicator-virus dose variation and had antiviral effect of shorter duration than the virus-induced and animal cell-translated interferon. The BTIF, probably, due to the action of bacterial proteolytic enzymes proved nonstable on storage.
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