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  • Title: A gamma and G gamma globin chain synthesis in BFU-E colonies from adult, newborn, and fetal subjects and from thalassemic patients.
    Author: Testa U, Guerrasio A, Vainchenker W, Saglio G, Rouyer-Fessard P, Chabret C, Beuzard Y, Rosa J.
    Journal: J Lab Clin Med; 1980 Nov; 96(5):790-5. PubMed ID: 6158541.
    Abstract:
    The G gamma and A gamma content of Hb F produced in cultures of BFU-Es from the blood of normal fetuses, neonates, and adults was determined. The results show that erythroid progenitors produce A gamma and G gamma chains in a ratio characteristic of their ontogenic stage. The analysis of the G gamma/A gamma ratio in culture of BRU-Es from thalassemic patients showed a marked heterogeneity, resembling that observed in freshly drawn cells. These results afford evidence that the type of gamma chain produced is programmed at the level of early erythroid progenitors.
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