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  • Title: Effects of spinal cord lesions on somatic evoked potentials altered by interactions between afferent inputs.
    Author: Martin HF, Katz S, Blackburn JG.
    Journal: Electroencephalogr Clin Neurophysiol; 1980 Oct; 50(1-2):186-95. PubMed ID: 6159186.
    Abstract:
    In cats anesthetized with alpha-chloralose, somatic evoked potentials (SEP) were recorded in response to electrical stimulation of surgically isolated peripheral nerves. Selected surgical lesions were made at T9-L1 spinal cord and were histologically verified. Two stimulus magnitudes were used to activate peripheral nerves, one only exciting the large fibers and another exciting the small fibers as well. Control SEPs were recorded in response to stimulation of both large and small fibers of the radial nerve. The later components (latencies greater than 40 msec) of this SEP were suppressed when evoked 100 msec after application of a conditioning stimulus (CS) to the large fibers of either peroneal nerve. Bilateral transection of the dorsal columns and spinocervical tracts eliminates these effects. Increasing the CS intensity to include small diameter fibers again resulted in reduction of the later components of the SEP. This interaction was largely eliminated if the transection was extended to include mid-lateral cord tracts. These results suggest that the SEP can be influenced by small fiber afferent activity conducted in mid-ventrolateral spinal cord in the absence of the dorsal columns and spinocervical tracts. Alterations in the forelimb-evoked SEP by a conditioning hindlimb stimulus is a sensitive indicator of spinal cord integrity. This method may be used to assess whether low spinal injury spares ventrolateral columns.
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