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  • Title: Role of macrophage-dependent determinant selection in induction phase of streptococcal carditis.
    Author: Dos Reis GA, Barcinski MA.
    Journal: Lancet; 1980 Oct 11; 2(8198):777-9. PubMed ID: 6159508.
    Abstract:
    A genetically controlled antigen-presentation function in macrophages is proposed to explain the induction phase of streptococcal carditis. Antigenic determinants in strains of beta-haemolytic streptococci causing rheumatic fever are selected by macrophages, through the operation of immune response (Ir) genes, to be presented to T lymphocytes. Cross-reactivity between the selected determinants and heart tissue components generates clones of autoreactive T cells. Autoimmunity will develop if, coincidental with the presentation of the relevant antigenic determinant, regulation of T-cell production is disturbed. This hypothesis explains the capacity of different strains of streptococcus to produce rheumatic fever and also the variability in host susceptibility to the disease.
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