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  • Title: Etiology of otitis media with effusion: antihistamines--decongestants.
    Author: Peerless SA, Noiman AH.
    Journal: Laryngoscope; 1980 Nov; 90(11 Pt 1):1852-64. PubMed ID: 6159516.
    Abstract:
    In an attempt to find a causative factor for the increased incidence of otitis media with effusion, a detailed study of 50 cases was conducted. This study included 50 cases of nonpurulent otitis media with effusion requiring ventilating tubes without tonsilloadenoid pathology. A study of these cases revealed an interesting pattern which suggests that antihistamines and decongestants may be causative or precipitating factors in the etiology of otitis media with effusion. A pilot study on the effects of these drugs on mucociliary activity was conducted and revealed further evidence that antihistamines and decongestants interfere with normal mucociliary activity which probably is a factor in abnormal Eustachian tube physiology.
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