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  • Title: Hypogammaglobulinemia and Nocardia brain abscesses.
    Author: Murray KJ, Ackerman SK, Chou SN, Douglas SD.
    Journal: Neurosurgery; 1977; 1(3):297-9. PubMed ID: 615978.
    Abstract:
    The host defense responses to Nocardia asteroides are not known. We have investigated a patient with common variable adult onset hypogammaglobulinemia who developed fatal disseminated nocardiosis. The patient had low levels of serum immunoglobulins; the total lymphocyte count was normal as were the percentages of circulating T and B cells. Transmission electron microscopic studies demonstrated typical N. asteroides within the brain parenchyma and nonspecific inflammatory changes in the central nervous system. The findings suggest that humoral immunity may play a major role in the host defense of patients with this disease.
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