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  • Title: Value of beta 1C/1A globulin serum levels as an early index of glomerular involvement in Schistosoma mansoni infection.
    Author: Martinelli R, Brito E, Rocha H.
    Journal: Am J Trop Med Hyg; 1980 Sep; 29(5):882-5. PubMed ID: 6159796.
    Abstract:
    In attempting the early detection of glomerular abnormalities in patients with the hepatosplenic form of Schistosoma mansoni infection, the serum concentration of beta 1C/1A globulin was determined in 17 patients without clinical evidence of nephropathy. Renal biopsies were obtained during splenectomy in all of them. The serum levels of beta 1C/1A globulin were below the normal limit in eight patients; of these, two had histological evidence of focal proliferative glomerulonephritis, two others had membranoproliferative glomerulonephritis, and one showed focal sclerosing glomerulonephritis. Of nine patients with normal serum levels of beta 1C/1A globulin, eight had no glomerular abnormalities demonstrated by light microscopy. Determination of the serum concentration of beta 1C/1A globulin proved to be a valuable index for the detection of early glomerulopathy in patients with hepatosplenic schistosomiasis, since a low level correlated well with the histologic demonstration of glomerular involvement by light microscopy.
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