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  • Title: [Influence of procaine and nicotinoyl-procaine on enzyme activities, nucleic acid and protein synthesis in primary cultures of heart and skeletal muscle cells of rats (author's transl)].
    Author: Freimüller B, Müller WH, Lamprecht W.
    Journal: Arzneimittelforschung; 1980; 30(10):1641-3. PubMed ID: 6159898.
    Abstract:
    The comparative studies are continued on the influence of two tertiary amines, procaine and nicotinoyl-procaine, on isolated heart and skeletal muscle cells in culture. A daily addition of these substances to cell cultures produces an increase in the specific activities of glutamate dehydrogenase and glutamate-oxaloacetate transaminase and an inhibition of alteration in the isoenzyme pattern of lactate dehydrogenase. The presence of procaine or nicotinoyl-procaine, resp., inhibits thymidine incorporation by cells in culture, whereas the incorporation of thymidine is increased after pretreatment of cells with these substances. These results support the findings of an influence of said tertiary amines on the metabolism of cells in culture.
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