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  • Title: Acetylcholinesterase and fetal malformations: modified qualitative technique for diagnosis of neural tube defects.
    Author: Haddow JE, Morin ME, Holman MS, Miller WA.
    Journal: Clin Chem; 1981 Jan; 27(1):61-3. PubMed ID: 6160926.
    Abstract:
    A single-blind study involving amniotic-fluid samples from 214 pregnancies of known outcome confirms that an electrophoretically distinct isoenzyme of acetylcholinesterase is associated with fetal open neural tube defects. Furthermore, only one of 13 amniotic-fluid samples with false-positive results for alpha-fetoprotein showed the characteristic isoenzyme, indicating that qualitative acetylcholinesterase assessment can decrease the proportion of false positives from the alpha-fetoprotein assay. We have also identified this characteristic isoenzyme in amniotic fluids from pregnancies in which other serious fetal defects occurred. A detailed electrophoresis protocol for identifying this characteristic isoenzyme is described.
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