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  • Title: Bleomycin-mediated DNA cross-links are dependent on closed-circular molecules with superhelical turns.
    Author: Lloyd RS, Robberson DL, Haidle CW.
    Journal: Chem Biol Interact; 1981 Feb; 34(1):39-46. PubMed ID: 6161707.
    Abstract:
    Non-covalent intermolecular DNA cross-links are created by reaction with the antitumor antibiotic, bleomycin. The cross-links are observed only when the reactant covalently closed circular duplex DNA contains either positive or negative superhelical turns. Multiple sites of cross-linking often extend over 500 base-pairs or more in length.
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