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  • Title: [Effects of acute hypercapnia upon the myocardium: contractility, coronary resistance, oxygen consumption and potassium balance (author's transl)].
    Author: Mosca SM, Casarini A, Iveli CA, Escudero EM, Cingolani HE.
    Journal: Acta Physiol Lat Am; 1977; 27(2):72-9. PubMed ID: 616176.
    Abstract:
    In the isolated perfused dog heart, at constant coronary blood flow and heart rate, we studied the effect of altering CO2 in the gas mixture from 5 to 15% on contractility, coronary resistance, myocardial O2 consumption and K balance. Contractility, assessed by the developed force, and its derivative through a strain-gauge arch sewed to the left ventricle decreased to 54 +/- 7% (p less than 0.01) and 59 +/- 6% (p less than 0.01), respectively from control values. Coronary resistance decreased to 79 +/- 3% of control ( less than 0.01). The negative inotropic effect of hypercapnia was accompanied by a decrease in myocardial O2 consumption to 68 +/- 11% (p less than 0.01) of control value and a net uptake of K by the heart. The possibility of an exchange of H+ by K+ is suggested as a possible mechanism involved in the negative inotropic effect of hypercapnia.
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