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  • Title: Effects of topical erythromycin on aerobic and anaerobic surface flora.
    Author: Bernstein JE, Shalita AR.
    Journal: Acta Derm Venereol; 1980; 60(6):537-9. PubMed ID: 6162344.
    Abstract:
    The contents of acne lesions from 30 men with inflammatory acne vulgaris, obtained before and at the conclusion of 4 weeks of topical 2% erythromycin therapy, were cultured on aerobic and anaerobic plates. Sensitivity testing of cultures was performed with discs containing 50 mg erythromycin, in order to ascertain the prevalence of erythromycin-resistant strains of Propionibacterium acnes and aerobic micrococci. The percentages of patients in whom erythromycin-resistant micrococci could be isolated increased from 3 to 60% during topical erythromycin therapy, but no resistant P. acnes strains were isolated either before or after therapy. Considering the widespread use of topical antibiotics, long-term studies on their ecological effects are desirable.
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