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  • Title: Platelet heterogeneity and dense tubular system changes on activation.
    Author: Yarom R, Lijovetzky G, Havivi Y.
    Journal: Experientia; 1981 Jan 15; 37(1):96-8. PubMed ID: 6162675.
    Abstract:
    Platelets impregnated with heavy metals appeared as 3 distinct morphological types: 'reticular' cells with a polygonal dense tubular network and stained granules, dark metallophilic cells, and pale metallophobic cells with microvesicles and non-staining granules. On stimulation, type 1 cells decreased while type 3 cells increased, suggesting that with activation dense tubules break up into microvesicles and granules become metallophobic. In the type 2 cells a different functional mechanism may exist.
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