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  • Title: [Lymphatic manifestation forms in the terminal phase of chronic myelocytic leukemia].
    Author: Bucher U, Zimmermann A, Coninx S, Köpp P.
    Journal: Folia Haematol Int Mag Klin Morphol Blutforsch; 1980; 107(4):574-82. PubMed ID: 6162726.
    Abstract:
    A blastic transformation in chronic myeloic leukaemia (CML) is reported, which, on the one hand, is characterized by the "lymphoid" feature of blasts and, on the other hand, by the appearance of great lymph node swellings. The clear distinction from (secondary) malignant lymphomas may be difficult. The inclusion of such forms of blastic transformation in CML is based on cytogenetic findings. Their non-granulocytic or "lymphoid" nature emerges from their cytological behavior. The fact that these lymphoid transformations respond to vincristin and prednison emphasize that their recognition as special entities is justified. They also demonstrate that the neoplastic process in CML may not only involve myelopoietic but pluripotent stem cells as well.
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