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  • Title: Mode of action of coronary arterial relaxation by prostacyclin.
    Author: Holzmann S, Kukovetz WR, Schmidt K.
    Journal: J Cyclic Nucleotide Res; 1980; 6(6):451-60. PubMed ID: 6163806.
    Abstract:
    Subsequent to previous observations suggesting a close association between the relaxing actions of PGI2 and its increasing effects on cyclic AMP levels in bovine coronary smooth muscle, evidence indicative of a transmitter function of cAMP in PGI2-induced relaxation is presented, by showing that a) in time course experiments in circular strips of bovine coronary arteries the increase in cAMP-levels caused by PGI2 preceded the mechanical response, b) the relaxant as well as cAMP-increasing effects produced by PGI2 were significantly potentiated by the PDE-inhibitor MIX, and c) in a particulate preparation of bovine coronary arteries PGI2 concentration dependently stimulated adenylate cyclase in the presence of GTP.
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