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  • Title: Absence of L-histidine lyase and histidine imidazole metabolites in human adenomatous prostate.
    Author: van Sande M, Van Camp K.
    Journal: Urol Int; 1980; 35(6):417-20. PubMed ID: 6164144.
    Abstract:
    The histidine metabolism in homogenates of human tissues of nontreated benign prostatic hyperplasia has been examined by means of the determination of L-histidine ammonia lyase activity (EC 4.3.1.3;histidine alpha-deaminase, histidase) and the histidine imidazole metabolites which were separated by means of ion exchange chromatography. Neither enzymatic activity nor metabolites of histidine could be detected. It is concluded that non-treated benign prostatic hyperplasia lacks L-histidine ammonia lyase activity and subsequently the metabolic pathway of histidine.
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