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  • Title: Carcinogenicity of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2) fed to female Sprague-Dawley rats.
    Author: Cohen SM, Ichikawa M, Bryan GT.
    Journal: Gan; 1977 Aug; 68(4):473-6. PubMed ID: 616417.
    Abstract:
    The carcinogenicity of 2-(2-furyl)-3-(5-nitro-5-furyl)acrylamide (AF-2) was investigated by administering it orally to Sprague-Dawley female weanling rats in a grain diet at a dose of 0.2% for 46 weeks, followed by 20 weeks of unmedicated control diet. The total mean cumulative dose of AF-2 was 10.1 g (41.6 mmol) per rat during the 46 weeks of the experiment. Weight gains of rats fed AF-2 was comparable to that of unmedicated control rats. Survival of rats fed AF-2 was 52 +/- 12 (SD) weeds compared to 65 +/- 5 weeks for the unmedicated controls (P less than 0.001). Twenty-four of 29 rats fed AF-2 developed multiple breast tumors, 15 of which were adenocarcinomas. Two of 29 unmedicated control rats had single fibroadenomas of the breast.
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