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  • Title: Pregnancy-associated plasma protein A: circulating levels during normal pregnancy.
    Author: Folkersen J, Grudzinskas JG, Hindersson P, Teisner B, Westergaard JG.
    Journal: Am J Obstet Gynecol; 1981 Apr 15; 139(8):910-4. PubMed ID: 6164292.
    Abstract:
    The development of specific and sensitive electroimmunoassays for a recently identified high molecular weight alpha-2 mobile pregnancy-specific protein (pregnancy-associated plasma protein A, PAPP-A or SP4) is described. These assays have permitted the detection of circulating levels of PAPP-A (10 microgram/L) as early as the fifth week of pregnancy. In all 18 subjects studied, the levels of PAPP-A rose from first detection in the first trimester until delivery at term. The development of these assays now permit the evaluation of PAPP-A measurement as a diagnostic test of early pregnancy and as an index of fetal well-being throughout gestation.
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