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  • Title: [Effect of mitogens on suppression of antibody formation and proliferation in dense cultures].
    Author: Korukova AA, Kim AB, Gurvich AE.
    Journal: Biull Eksp Biol Med; 1981 Feb; 91(2):188-90. PubMed ID: 6164414.
    Abstract:
    A study was made of the effect of mitogens on general proliferation and primary immune response to sheep red blood cells in density-inhibited cultures of mouse spleen cells. The mitogens applied included fetal calf serum and both B cell- and T cell-specific mitogens (dextran sulfate, LPS and ConA). Experiments with 3H-thymidine incorporation demonstrated that the proliferation was equally enhanced by any mitogen in both optimal and density-inhibited cultures. The mitogens did not remove the density inhibition of antibody formation.
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