These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of intracerebroventricular administration of substance P and its hexapeptide fragment on the estrus cycle in female rats.
    Author: Jakubowska-Naziembło B, Włodzimierska B, Traczyk WZ.
    Journal: Acta Physiol Pol; 1980; 31(6):637-45. PubMed ID: 6166149.
    Abstract:
    The purpose of the reported experiments was the study of the effects of intracerebroventricular (i.c.v.) administration of substance P (SP 1--11) and its hexapeptide C-terminal fragments SP 6--11 and (pGlu6)SP6--11 on the length of the estrus cycle. In the animals with a regular sequence of estrus aliquots of 250 pmol of the three peptides: SP 1--11, SP 6--11 and (pGlu6)SP 6--11 on the carier dextrane were infused into the left lateral cerebral ventricle through a chronically implanted cannula. For control, dextran solution in 0.9% NaCl was infused in a similar way. I.c.v. infusion of dextran in 0.9% NaCl, SP 1--11 and (pGlu6)SP 6--11 caused no significant changes in the length of the estrus cycle during which the infusion was done. Infusion of SP 6--11 prolonged the diestrus phase in most animals. This observation indicates that SP 6--11 exerted an effect on the hypothalamic mechanism controlling the secretion of gonadotropins by the hypophysis.
    [Abstract] [Full Text] [Related] [New Search]