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  • Title: A modulation of the anaphylactic basophil histamine release by selective H2 histamine agonists.
    Author: Kazimierczak W, Szczepaniak K, Bańkowska K.
    Journal: Agents Actions; 1981 Apr; 11(1-2):96-8. PubMed ID: 6166177.
    Abstract:
    Two selective H2-histamine agonists, dimaprit and impromidine, have been tested for their action on histamine release from human basophils and rat mast cells. IgE-mediated basophil histamine release was inhibited by stimulation of histamine H2-receptors. However, differences between the actions of both dimaprit and impromidine were noticed. Both impromidine and dimaprit had no specific effect on 48/80-induced histamine release from rat mast cells, although the latter in higher concentrations either slightly increased spontaneous histamine release or non-specifically inhibited compound 48/80-induced release. The results are consistent with the view that activation of adenylate cyclase via H2-histamine receptors might be an important regulatory mechanism of histamine release from human basophils but not from rat mast cells.
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