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  • Title: [Turnover of chromatin proteins in rat liver during induction of RNA synthesis by electrostimulation of the hypothalamus].
    Author: Tiulenev VI, Kapralov AA, Masiuk AI.
    Journal: Biokhimiia; 1980 Sep; 45(9):1669-74. PubMed ID: 6166330.
    Abstract:
    It has been shown that the induction of D-RNA synthesis in rat liver nuclei by electrostimulation of hypothalamus is accompanied by a decrease in chromatin protein synthesis and an increase in phosphorylation and acetylation of chromatin proteins. The decrease of the histone synthesis is mainly due to the decrease of [14C]lysine and [14C]alanine incorporation into histones H1 and H4. The relationship between H1, H2b-H3, H2a and H4 histone fractions remains unchanged. Electrostimulation of hypothalamus increases acetylation of H2a and H4 histone fractions and phosphorylation of all histones with the exception of histone H1.
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