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  • Title: HLA antigens in juvenile dermatitis herpetiformis.
    Author: Richiardi P, Borelli I, Malavasi F, Curtoni ES, Berti E, Gianotti F, Giannetti A.
    Journal: Acta Derm Venereol; 1981; 61(3):241-4. PubMed ID: 6167108.
    Abstract:
    The incidence of histocompatibility antigens HLA-A, B, C, DR was studied in 32 Italian children with dermatitis herpetiformis. A significantly increased relative risk was found for B8 (R.R.=6.2), which was present in 50% of the patients as against 14% of the controls and for DR3 (R.R.=11.7), present in 69% of the patients as against 16%. DR7 also appeared to be increased, but only among DR3-negative patients. There was no significant difference in the incidence of DR3 between children with abnormal and normal jejunal biopsy, though there does seem to be a difference in expressivity of the intestinal involvement between DR3 apparent homozygous, DR3 heterozygous and DR3-negative patients.
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