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  • Title: [Lingual taste buds following application of colchicine to the glossopharyngeal nerve in the rat].
    Author: Chelyshev IuA, Zefirov TL, Ivanov VM.
    Journal: Biull Eksp Biol Med; 1981 May; 91(5):525-7. PubMed ID: 6167300.
    Abstract:
    Dissection of the glossopharyngeal nerve and application to it of colchicine that blocks axoplasmic drug transport were performed to study the effect of the nerves on the taste buds of foliate lingual papillae. It was observed that colchicine application to the nerve gave rise to destruction of the taste buds. The process of destruction proceeded more slowly as compared to that induced by nerve dissection. Colchicine application led to changes in the protein spectrum of the epithelium of foliate papillae. The absence of changes in the protein spectrum of the epithelium of foliate papillae and the presence of nerve fibers in the epithelium of the taste buds on exposure to colchicine provide evidence against its direct toxic effect on the taste buds, giving rise to their destruction. The changes seen in the taste buds result from the blocked transport of factors that participate in neurotropic control of the taste buds.
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