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  • Title: Increased amnionic fluid alpha-fetoprotein due to a holoacardium amorphous twin.
    Author: Harger JH, Doshi N, Marchese S, Hinkle RS, Garver KL.
    Journal: Clin Genet; 1981 Apr; 19(4):257-61. PubMed ID: 6168421.
    Abstract:
    Amnionic fluid alpha-fetoprotein measurement was employed as a screening test for neural tube defects in a pregnancy only at risk due to advanced maternal age. The alpha-fetoprotein concentration was elevated more than 10 standard deviations above the mean and was found to be caused by a holoacardium amorphous twin. A normal female fetus was also present. Various causes of elevated alpha-fetoprotein concentration in amnionic fluid are discussed.
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