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  • Title: Involvement of the spleen in the control of the immunogenic and phagocytic function of thioglycollate-induced macrophages.
    Author: Ron Y, De Baetselier P, Feldman M, Segal S.
    Journal: Eur J Immunol; 1981 Aug; 11(8):608-11. PubMed ID: 6168471.
    Abstract:
    The immunogenic capacity of thioglycollate-induced peritoneal macrophages of adult splenectomized animals was compared to that of macrophages of sham-operated controls. Macrophages from splenectomized animals were found to be impaired in their function as antigen-presenting cells, both in the education of virgin initiator T lymphocytes and in the stimulation of antigen-specific T memory cells. Macrophages from splenectomized animals were also severely impaired in their phagocytic capacity, as assessed in an opsonin-dependent bacterial phagocytosis assay. However, they were not impaired in their ability to pinocytose soluble keyhole limpet hemocyanin. These results indicate that the spleen may play a decisive role in controlling the differentiation of peritoneal macrophages.
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