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  • Title: Effects of oxprenolol on the intra-arterial blood pressure response to dynamic exercise in hypertensive men.
    Author: Millar-Craig MW, Mann S, Balasubramanian V, Cashman P, Raftery EB.
    Journal: J Cardiovasc Pharmacol; 1981; 3(3):468-76. PubMed ID: 6168828.
    Abstract:
    The intra-arterial blood pressure of 20 male patients with essential hypertension was continuously recorded during dynamic exercise. Graded exercise testing on a bicycle ergometer and a stair-climbing test were performed prior to and during treatment with oxprenolol. Acute oxprenolol therapy was associated with a reduction in heart rate but little reduction in blood pressure. Chronic treatment for 14.3 weeks with oxprenolol (mean daily dose, 344 mg) was associated with a substantial reduction of blood pressure at rest and at each level of bicycle exercise. A similar antihypertensive effect was demonstrated during stair climbing. The normal blood pressure response to exercise as assessed by the relative (percentage) increase in pressure above the pre-exercise level and the rate of increase in blood pressure (per unit of work), as well as exercise tolerance, were unchanged by chronic beta-blockade with oxprenolol.
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