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  • Title: [Natural antibodies against Pseudomonas aeruginosa in human gamma globulin preparations].
    Author: Chekan LV, Min'ovich FL, Kutimova LR, Edvabnaia LS, Stanislavskiĭ ES.
    Journal: Zh Mikrobiol Epidemiol Immunobiol; 1981 Jun; (6):85-9. PubMed ID: 6170196.
    Abstract:
    A total of 191 batches of commercial human gamma globulin were studied with the aim of detecting natural antibodies by means of cross and countercurrent electrophoresis, immunodiffusion in agar gel and the passive hemagglutination test. Commercial human gamma globulin preparations were found to contain, to a greater or lesser extent, natural antibodies to the cell-wall O-antigen of Ps. aeruginosa and the antigens of its extracellular slime (capsule); the titers of these antibodies were 1 : 64 to 1 : 256 in 75-85% of cases, 1 : 512 and greater in 10-11% of cases. Commercial gamma globulin preparations also contained antibodies protecting mice from experimental Pseudomonas infection. No correlation was detected between the degree of serological activity and the protective activity of gamma globulin preparations.
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