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  • Title: Complement activation requirements for histamine release from human leukocytes: influence of purified C3ahu and C5ahu on histamine release.
    Author: Hartman CT, Glovsky MM.
    Journal: Int Arch Allergy Appl Immunol; 1981; 66(3):274-81. PubMed ID: 6170591.
    Abstract:
    The activation of human sera for histamine release by zymosan and anti-BSA-BSA complexes at equivalence was dose dependent and associated with a marked fall in CH50, C3 and C5 hemolytic activities. Heat-aggregated IgG, though able to fix greater than 90% of human CH50 activity and produce a lesser fall in C3 and C5 activities than zymosan and BSA-anti-BSA complexes, was unable to induce basophil histamine release. Chemically purified human C3a and C5a each caused histamine release from human basophils; C5a was more potent than C3a. In addition, neither zymosan nor BSA-anti-BSA complexes released histamine when incubated with homozygous C3-deficient serum. The addition of C3a and C5a at suboptimal concentrations produced an additive effect of histamine release.
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