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  • Title: Neuroendocrine and neurochemical measurements in depression.
    Author: Davis KL, Hollister LE, Mathé AA, Davis BM, Rothpearl AB, Faull KF, Hsieh JY, Barchas JD, Berger PA.
    Journal: Am J Psychiatry; 1981 Dec; 138(12):1555-62. PubMed ID: 6171169.
    Abstract:
    The authors performed dexamethasone suppression tests (DST), TRH infusions, 72-hour urine collections, and lumbar punctures on a group of male depressed patients. Approximately 60% of the patients were DST positive and 33% had a blunted TSH response. Two biologic variables, the 8 a.m. postdexamethasone cortisol and the postprobenecid CSF 5-hydroxyindoleacetic acid (5-HIAA), accounted for over half of the variance in the behavioral measure, the Hamilton score. Plasma cortisol elevation was associated with high 3-methoxy-4-hydroxyphenyl glycol (MHPG) excretion; TSH blunting was associated with low urinary MHPG excretion. Comprehensive biologic measures showed certain significant interrelationships and correlations with the severity of depression.
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