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  • Title: [DNA and RNA synthesis in isolated nuclei of rat skeletal muscle fibers following hypokinesia].
    Author: Fedorov IV, Komolova GS, Chernyĭ AV.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1981 Oct; 67(10):1521-4. PubMed ID: 6172293.
    Abstract:
    Incorporation of labelled nucleotides [3H] UTP and [3] TTP revealed the intensity of DNA and RNA synthesis in the skeletal muscle nuclei in vitro in the male rats of Wistar line after 22-day immobilization. The RNA biosynthesis (the intensity of transcription) considerably diminished in the skeletal muscle nuclei of hypokinetic rats (by 1.8 times). No differences developed in the actinomycin D depression of r-RNA and s-RNA synthesis. The DNA biosynthesis (the intensity of replication) also decreased. The depression of DNA and RNA biosynthesis seems to be the main reason of the decreased intensity of protein synthesis in the rat skeletal muscle during hypodynamia.
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