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  • Title: Induction of IgM memory with RNA from the spleens of immunized mice.
    Author: Kodama K, Yoshida T, Shibiya T, Kurashige S, Mitsuhashi S.
    Journal: Immunology; 1981 Nov; 44(3):535-42. PubMed ID: 6172370.
    Abstract:
    Ribonucleic acid (immune RNA, iRNA), extracted from the spleens of mice immunized with sheep red blood cells (SRBC), induced specific immunological memory. The humoral immune responses of iRNA-treated animals were compared with in vivo and in vitro primary and secondary responses, using the haemolytic plaque-forming cell (PFC) assay. IgM antibody formation was markedly higher in iRNA-treated than in any other mice. The effect of iRNA was antigen-specific and similar materials from non-immunized mice had no activity.
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