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  • Title: D-penicillamine induced changes on rat mast cell cyclic GMP levels.
    Author: Schinetti ML, Greco R, Bertelli A.
    Journal: Int J Tissue React; 1981 Jun; 3(2):83-8. PubMed ID: 6173315.
    Abstract:
    The cGMP accumulation in rat serosal mast cells was measured after cell treatment with D-penicillamine, a sulphydryl containing compound. Preincubating the cells with increasing doses of the drug causes a decrease of basal level of the nucleotide. In cells activated with the degranulating agent 48/80 there is a sharp increase in cGMP intracellular levels. D-Penicillamine prevents the nucleotide accumulation caused by compound 48/80, decreasing even the steady-state level in activated cells. The effect on cGMP metabolism does not correspond to an inhibition of histamine release.
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