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  • Title: Induction of RNA polymerase II activity in Junin virus-infected cells.
    Author: Mersich SE, Damonte EB, Coto CE.
    Journal: Intervirology; 1981; 16(2):123-7. PubMed ID: 6173349.
    Abstract:
    Nuclear involvement of the host cell in Junin virus (JV) replication was studied. alpha-Amanitin was shown to inhibit JV yield, and RNA synthesis in cell nuclei was found to be augmented during the eclipse period. JV infection exerted a selective effect on cellular RNA polymerase activities, when measured in purified infected nuclei. RNA polymerase I was inhibited, but RNA polymerase II was stimulated. These data support the hypothesis that RNA polymerase II is involved in arenavirus replication.
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