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  • Title: Direct evidence for the involvement of T suppressor cells in the expression of low-dose paralysis to type III pneumococcal polysaccharide.
    Author: Baker PJ, Amsbaugh DF, Stashak PW, Caldes G, Prescott B.
    Journal: J Immunol; 1982 Mar; 128(3):1059-62. PubMed ID: 6173416.
    Abstract:
    Prior treatment (priming) with a subimmunogenic dose of type III pneumococcal polysaccharide results in the development of an antigen-specific state of unresponsiveness termed low-dose paralysis. Such unresponsiveness can be transferred by spleen cells obtained from mice within 5 to 24 hr after priming; the suppressive activity of transferred cells is abolished by treatment with monoclonal anti-Thy-1.2 antibody and complement. These findings show clearly that low-dose paralysis is mediated by T suppressor cells.
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