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  • Title: MLC-specific suppressor T lymphocytes in man. I. Their induction in vitro by soluble HLA-DR antigens.
    Author: Smeraldi RS, Fabio G, Bonara P, Villa MG, Vanoli M, Pettenati C, Rugarli C, Zanussi C.
    Journal: J Immunol; 1982 Mar; 128(3):1394-8. PubMed ID: 6173435.
    Abstract:
    Human T lymphocytes precultured for 36 hr in the presence of soluble HLA-DR antigens suppress the MLR response of autologous peripheral blood lymphocytes to allogeneic stimulating cells. The suppression is DR antigen-specific in that it appears that the MLR stimulating cell donor and the soluble suppressor-inducing antigen must share DR specificities. The soluble DR antigens were fractionated from the sera of normal donors using QAE-Sephadex chromatography and CNBr-activated Sepharose immunoadsorption. Similarly prepared HLA-A and -B antigens failed to induce suppressive activity. The suppressive activity of DR-antigen cultured T cells is resistant to mitomycin C treatment and, further, the antigen specificity is maintained with or without mitomycin C treatment. The kinetics of suppressor cell induction as well as the kinetics of suppression in the test MLR cultures are presented. The implications of these results are discussed.
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