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  • Title: Gradients of monoamine metabolites and cortisol in cerebrospinal fluid of psychiatric patients and healthy controls.
    Author: Bertilsson L, Asberg M, Lantto O, Scalia-Tomba GP, Träskman-Bendz L, Tybring G.
    Journal: Psychiatry Res; 1982 Feb; 6(1):77-83. PubMed ID: 6173891.
    Abstract:
    Amine metabolites and cortisol were measured in four consecutive 3 ml samples of lumbar cerebrospinal fluid (CSF). There were pronounced concentration gradients for both 5-hydroxyindoleacetic acid and homovanillic acid, and there was no difference in the gradients of 11 controls and 17 psychiatric patients (10 depressed). As there was a close correlation between the mean of the first two fractions and the mean of all four fractions, a concentration obtained in 6 ml can be used to calculate that in a 12 ml CSF sample. In psychiatric patients there was a slight, but statistically significant concentration gradient for 3-methoxy-4-hydroxyphenylglycol (unconjugated as well as conjugated). No gradient was found for cortisol in CSF.
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