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  • Title: [Incorporation of [2-14C orotic] acid into chromatin RNA of tissues of animals of various ages].
    Author: Mozzhukhina TG, Khilobok IIu, Gol'dshtein NB.
    Journal: Ukr Biokhim Zh (1978); 1982; 54(1):73-6. PubMed ID: 6173948.
    Abstract:
    The structure and biological activity (the level of the labelled precursor incorporation into RNA) of active and repressed chromatin of the liver and small intestine mucosa were studied in adult (6-8 months) and old (24-26 months) rats. The content of repressed chromatin fraction in both tissues is found to increase with age. In the liver of old rats the level of [14C[ orotic acid incorporation into RNA of chromatin fractions decreases, radioactivity of the acid-soluble fraction being unchanged. In the small intestine mucosa a high leve of [14C] orotic acid incorporation into chromatin RNA with ageing is due to an increase in permeability of the mucosa cells.
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