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  • Title: Depletion of primary afferent substance P by capsaicin and dihydrocapsaicin without altered thermal sensitivity in rats.
    Author: Buck SH, Miller MS, Burks TF.
    Journal: Brain Res; 1982 Feb 04; 233(1):216-20. PubMed ID: 6174176.
    Abstract:
    Systemic administration of capsaicin and dihydrocapsaicin to adult rats of two different strains and of capsaicin to neonatal rats, depleted substance P levels in dorsal roots plus ganglia and in dorsal spinal cord. In no case was this depletion accompanied by substantially altered tail-flick latencies. The results are not consistent with a role of the neuropeptide in nociceptive thermal sensitivity in the rat.
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