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  • Title: Calcium causes the biphasic dose-response curve for pancreatic amylase secretion.
    Author: Roberts ML, Woodland MJ.
    Journal: Experientia; 1982 Feb 15; 38(2):256-7. PubMed ID: 6174366.
    Abstract:
    High concentrations of bethanechol (10(-4) to 10(-3) M) were effective stimulants of amylase secretion from the mouse pancreas if incubations are performed in low [Ca2+] (0.1 mM) solutions but not if normal Krebs solution (2.56 mM Ca2+) was used. This inhibitory effect of Ca2+ at high secretagogue concentrations did not appear to be mediated through the microtubules or microfilaments.
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