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  • Title: Synergistic effect of cis-dichlorodiammineplatinum and 5-aza-2'-deoxycytidine on mouse leukemic cells in vivo and in vitro.
    Author: Veselý J.
    Journal: Int J Cancer; 1982 Jan 15; 29(1):81-5. PubMed ID: 6174463.
    Abstract:
    cis-Dichlorodiammineplatinum and 5-aza-2'-deoxycytidine display a considerable synergistic effect in L1210 and La mouse leukemia in vivo; the combination of both drugs is also clearly synergistic in vitro as evidenced by the effects on cell growth and cell survival in soft-agar medium. In exponential but not in stationary growth of L1210 cells, the drugs interfere with DNA and RNA synthesis.
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